Medioran

Composition:    Coated Tablets    Suppositories (Adult)    Suppositories (Child)    Syrup
Metoclopramide HCL    10 mg/ C. T.    20 mg/ Supp.    10 mg/ Supp.    5 mg/ 5 ml

Properties:
-    Medioran enhances the tone of the lower esophageal sphincter, increases the contractility of the antrum, relaxes the pylorus and duodenum, and thus it accelerates gastric emptying and intestinal transit. 
-    Medioran does not alter the acidity or the volume of the gastric secretion.

Indications:
-    Nausea and vomiting of any origin:
•    Post anesthesia and surgery.
•    Due to acidosis and Uremia.
•    Due to X-ray therapy or after radiological exploration.
•    Due to cancer chemotherapy.
-    Motility disorders: Pyloric spasm, biliary dyskinesea and lithiasis, flatulence, dyspeptic syndrome (dyspepsia), and liver cirrhosis.
-    Gastrointestinal disorders: Gastritis, esophagitis, peptic ulcer, results of gastrectomy and cholecystectomy, and gastric motor failure (post vagotomy, diabetic autonomic neuropathy).
-    Migraine (with other drugs).
-    Hiccup.

Cautions:
-    It should be used with caution in patients with severe or moderate renal failure (reduced about 50 %).
-    It should be used with caution in nursing mothers because it is secreted into mother’s milk.
-    Unless it’s very important, it must not be given during pregnancy.

Drug Interactions:
-    It increases the effect of central nervous system depressants.
-    It can not be used with anti-cholinergic agents.

Side Effects:
-    Extrapyramidal effects.
-    Drowsiness, dizziness, anxiety, diarrhea, and fatigue.
-    Effects on the endocrine glands: dysmenorrhea, gynecomastia, and prolactin hypersecretion.

Contraindications:
-    Epilepsy, gastrointestinal hemorrhage, mechanical obstruction, and pheochromocytoma.
-    Pheochromocytoma, and children under 20 kg weight.

Dosage & Administration:    Adults:    ½ - 1 Coated Tablet (5-10 mg)    3 times daily.
        1 Suppository (20 mg)    1-2 times daily.
    Adults:(15 year and over)    10 ml     3 times 30 minute brfore meals. 
    Children: (3-5 years)    1 Suppository (10 mg)    1-2 times daily.
    Children (5-9 years)    2.5 ml     3 times 30 minute brfore meals
    Children (9-15 years)    5 ml    3 times 30 minute brfore meals
Dose must not exceed 0.5 mg/ kg Body Weight    
Dose must be taken 30 minutes before meals.    

       
Presentation:            
Box contains:    20 Coated Tablets.    6 Suppositories (Adults)    
    100 ml of Syrup + measured spoon.    6 Suppositories (Children)