MEDIOPROFEN Coated Tablets- Oral Suspension
Non-Steroidal Anti-Inflammatory drug

Composition:
Coated Tablets: Each coated tablet contains 400 mg Ibuprofen.
Oral Suspension: Each 5ml of oral suspension contains 100 mg Ibuprofen.

Properties:
    Ibuprofen is a propionic derivative that inhibits prostaglandin synthesis.
    Medioprofen is a non-steroidal anti-inflammatory drug NSAIDS, analgesic and antipyretic.
    When taken oraly, peak serum level of Ibuprofen occurs 1-2 hours after ingestion.

Indications:
 
    Rheumatoid arthritis.
    Ankylosing Spondylitis.
    Osteoarthritis.
    Non-rheumatoid Arthropathies.
 

Periarticular conditions such as:    

 
    Bursitis.        Musculoskeletal disorders.        Traumatic cases, sprains.
    Low back pain.        Postoperative pain.        Frozen shoulder (capsulitis).
    Dental pain.        Tendinitis and Synovitis.        Soft tissue inflammatory conditions.
    
Side Effects:
    Abdominal discomfort, anorexia, diarrhea, tinnitus and gastrointestinal irritation.

Contraindications:
    Hypersensitivity to Ibuprofen.
    Hypersensitivity to Aspirin or other Non-Steroidal Anti-Inflammatory (NSAI) drugs.
    History of active peptic ulceration.
    Bronchospasm or asthma (relative contra-indication, as this medication may be administrated with observation).

Precautions:
    It should be given with care to patients with liver or renal failure.
    Avoid concomitant use with oral anticoagulants drugs (such as coumarin), as interactions have been reported in some patients.
    Caution is required in patients with a history of gastrointestinal disease (high risk of peptic ulceration).
    Like all drugs, Medioprofen must not be used during the first 3 months of pregnancy, and it’s not recommended during lactation.

Drug interactions:
    Ibuprofen increases the serum concentrations of both Digoxin and lithium.
    Severe and in some cases fatal aggravation of Methotrexate toxicity has been reported.
    In rare cases, Ibuprofen may increase the phenytoin toxicity.
    It may attenuate the hypotensive effect of some Antihypertensive drugs.
    It may increase the central adverse effects of quinolone antibiotics such as ciprofloxacine (this effect on CNS may lead to convulsions).
 

Dosage & Administration:

Medioprofen should be taken during or after meals.

Adults:     First dose: 1200 mg daily, (400 mg 3 times daily).
    Then the dose is decreased to the maintenance dose (600 – 800) mg daily.
    
Children:    The daily dosage of Medioprofen is 20 mg / kg of body weight in divided doses.
    Less than 30 kg, the total doses during 24 hours period should not exceed 500mg.
    Not recommended for children weighing less than 7 kg.
    
1-2 years:    One-half tea spoonful (2.5 ml = 50 mg) (3 - 4) times daily.
3-7 years:    One tea spoonful (5 ml = 100 mg) (3 - 4) times daily.
8-12 years:    Two tea spoonful (10 ml = 200 mg) (3 - 4) times daily.

Presentation:
Coated Tablets: Box contains 20 coated tablets.
Oral Suspension: Box contains a bottle of 100 ml.