CYPROVITAMINE Syrup

Composition:
Each 5 ml of CYPROVITAMINE syrup contains:
Cyproheptadine HCL     4 mg        Vitamin B6     0.67 mg
Vitamin B1     0.6 mg        Niacinamide     6.67 mg
Vitamin B2     0.75 mg        Vitamin C     21.67 mg

Properties:
    Cyproheptadine HCL is a histamine H1-receptor antagonist and serotonin antagonist.
    Vitamin C is essential for the synthesis of collagen and intercellular material.
    Vitamin B1 (Thiamine) is an essential coenzyme for carbohydrate metabolism.
    Vitamin B2 (Riboflavin) is essential for utilization of energy from food.
    Vitamin B6 is involved mainly in aminoacid metabolism. It is also involved in carbohydrate and fat metabolism. It is required for the formation of hemoglobin.
    Niacinamide in the form of NAD and NADP Coenzymes is involved in electron transfer reactions in the respiratory chain.

Indications: 
    CYPROVITAMINE syrup is indicated in symptomatic relief of hypersensitivity reactions including urticaria, angioedema, rhinitis and conjunctivitis, and in pruritic skin disorders. 
    CYPROVITAMINE syrup is used for appetite stimulation especially in anorexia nervosa.
    The adjunction of the Vitamins to cyproheptadine HCL prevents development of Vitamin deficiencies.

Side effects of antihistamines: 
Antimuscarinic effects: Dry mouth, thickened respiratory, tract secretions and tightness of the chest, blurred vision, urinary difficulty, and reduction in motility of gastro, intestinal tract resulting in constipation and increased gastric reflux; in high doses transient bradycardia followed by tachycardia with arrhythmias.

Overdose:
In adults CNS depression is more common with drowsiness, coma and convulsions progressing to respiratory failure or cardiovascular collapse.

Treatment of overdose effects: 
The stomach should immediately be emptied should then activated charcoal been given.

Precautions for H1-receptor antagonists (antihistamines):
    Antihistamines should not be given to premature infants or neonates or elderly patients since they have increased susceptibility to antimuscarinic effects.
    Patients on antihistamine treatment should not drive or operate machinery. They should avoid alcoholic drinks.

Vitamin administration adverse effects/ precautions to be taken: 
Large doses of Vitamin C are reported to cause diarrhea and other gastro-intestinal disturbances it may also result in hyperoxaluria and the formation of renal calcium oxalate calculi.

Interactions of antihistamines:
Antihistamine may enhance the sedative effects of CNS depressants: alcohol, barbiturates, hypnotics, opioid analgesics anaxiolytic sedatives and neuroleptics.

Contraindications:
Antihistamines should be used with precaution in closed angle-glaucoma, urinary retention, prostatic hypertrophy, or pyloroduodenal obstruction, asthma, epilepsy, severe cardiovascular disorders; liver disorders with MAOI.

Pregnancy and Lactation:
It should be used only under physician supervision.

Dosage and Administration:
It should not be used for children under 2 years of age.
Children (2 to 6) years: (2.5 ml = ½ tea-spoonfuls) twice daily.
              (7 to 14) years and Adults: (5 ml = 1 tea-spoonfuls) three times daily.

Appetite stimulant: 
•    Doses from the lower end of each dose range have been used to stimulate the appetite.

Presentation: 
Bottle contains 100 ml CYPROVITAMINE syrup.