Medioprofen
Non-Steroidal Anti-Inflammatory drug

Composition:
Each Medioprofen 400 coated tablet contains 400 mg Ibuprofen.

Properties:
-    Ibuprofen is a propionic derivative that inhibits prostaglandin synthesis.
-    Medioprofen is a non-steroidal anti-inflammatory, analgesic and antipyretic drug.
-    Taken on an empty stomach, peak serum level of Medioprofen occurs (1 – 2) hours after ingestion.
   
Indications:
 
-    Soft tissue inflammatory conditions.
-    Musculoskeletal disorders.
-    Postoperative pain.
-    Low back pain.
-    Dental pain.
-    Rheumatoid arthritis. 
-    Osteoarthritis.
-    Ankylosing spondylitis.
-    Non- rheumatoid arthropathies.
-    Traumatic cases, sprains.
 
-    Periarticular conditions such as:
 
•    Bursitis.    •    Tendonitis.
•    Frozen shoulder (capsulitis).    •    Synovitis.

Contraindications:
-    Hypersensitivity to ibuprofen.
-    Hypersensitivity to aspirin or other Non-Steroidal Anti-Inflammatory (N.S.A.I.) drugs.
-    Active peptic ulceration.
-    History of Bronchospasm or asthma (relative contra-indication, as Medioprofen may be administrated with observation).

Side effects:
Abdominal discomfort, anorexia, diarrhea, tinnitus, and gastrointestinal irritation.

Precautions:
-    It should be given with care to patients with severe liver or renal failure.
-    Avoid concomitant use with oral anticoagulants drugs (such as coumarin), as interactions have been reported in some patients.
-    Caution is required in patients with a history of gastrointestinal disease (high risk of peptic ulceration).
-    Like all drugs, Medioprofen must not be used during the first three months of pregnancy, and it’s not recommended during lactation.

Drug interactions:
-    Ibuprofen increases the serum concentration of both digoxin and lithium.
-    Severe, and in some cases fatal aggravation of methotrexate toxicity has been reported.
-    In rare cases it may increase the phenytoin toxicity.
-    It may attenuate the hypotensive effect of some anti-hypertensive drugs.
-    It may increase the central adverse effects of quinolone antibiotics such as ciprofloxacine (this effect on CNS may lead to convulsions).

Dosage & Administration:
-    Adults:    First dose: (1200 mg of Medioprofen) one tablet Medioprofen 400mg 3 times daily.
    Then the dose is decreased to the maintenance dose (600 – 800) mg daily.
-    Children:    20mg/kg of body weight daily.

Presentation:
Each box of Medioprofen 400 contains 20 coated tablets.